Simple Summary Pharmacological angiogenesis modulation was robustly demonstrated to
be a powerful clinical resource in oncotherapy. Adrenocortical carcinomas (ACC) often have
a poor prognosis for which therapeutic options are limited. Understanding the mechanisms
that regulate adrenocortical angiogenesis both under physiological conditions and in ACC
could provide important clues on how these processes could be modulated for clinical
purposes. This report summarizes the current knowledge on adrenal cortex angiogenesis …

Angiogenesis plays an important role in several physiological and pathological processes.
Pharmacological angiogenesis modulation has been robustly demonstrated to achieve
clinical benefits in several cancers. Adrenocortical carcinomas (ACC) are rare tumors that
often have a poor prognosis. In addition, therapeutic options for ACC are limited.
Understanding the mechanisms that regulate adrenocortical angiogenesis along the
embryonic development and in ACC could provide important clues on how these processes …