Cellular senescence and the senescent secretory phenotype in age-related chronic diseases
Y Zhu, JL Armstrong, T Tchkonia… - Current opinion in …, 2014 - journals.lww.com
Y Zhu, JL Armstrong, T Tchkonia, JL Kirkland
Current opinion in clinical nutrition & metabolic care, 2014•journals.lww.comAging is a complex biological process accompanied by a state of chronic, low-grade,'sterile'
inflammation, which is a major contributor to the development of many age-related chronic
disorders including atherosclerosis, osteoarthritis, Alzheimer's disease, type 2 diabetes,
cancers, and others. It appears that cellular senescence plays a role in causing inflammation
through the SASP. A better understanding of the contribution of senescent cells to the
pathologies of chronic inflammatory disorders could have potentially profound diagnostic …
inflammation, which is a major contributor to the development of many age-related chronic
disorders including atherosclerosis, osteoarthritis, Alzheimer's disease, type 2 diabetes,
cancers, and others. It appears that cellular senescence plays a role in causing inflammation
through the SASP. A better understanding of the contribution of senescent cells to the
pathologies of chronic inflammatory disorders could have potentially profound diagnostic …
Summary
Aging is a complex biological process accompanied by a state of chronic, low-grade,‘sterile’inflammation, which is a major contributor to the development of many age-related chronic disorders including atherosclerosis, osteoarthritis, Alzheimer's disease, type 2 diabetes, cancers, and others. It appears that cellular senescence plays a role in causing inflammation through the SASP. A better understanding of the contribution of senescent cells to the pathologies of chronic inflammatory disorders could have potentially profound diagnostic and therapeutic implications.
Lippincott Williams & Wilkins