Angiogenesis plays a vital role in the development of bladder cancer (BC). The Y‐box‐binding protein 1 (YB‐1) is a well‐known oncoprotein which is closely related to angiogenesis of tumors, but the relationship and mechanism of YB‐1 and angiogenesis in BC remain unclear. Based on 56 clinical BC specimens, this study found that high expression of YB‐1 samples demonstrated a higher expression of vascular endothelial growth factor A (VEGFA) than those of YB‐1 low expression. Subsequently, the expression of YB‐1 and miR‐29b‐3p was regulated in the BC cell lines where we noted that YB‐1 promoted VEGFA expression by downregulating the expression of miR‐ 29b‐3p. The ability of BC cells to induce angiogenesis decreased after YB‐1 was knocked down. Moreover, the in vivo study further confirmed that YB‐1 promotes angiogenesis in BC. Our findings enhance the understanding of how YB‐1 promotes angiogenesis in BC and provide evidence for YB‐1 as a therapeutic target of BC. Moreover, this may provide new inspiration for miRNAs replacement therapies.